Plasma exchange for concurrent lupus nephritis and antiphospholipid syndrome
نویسندگان
چکیده
Systemic lupus erythematosus (SLE) can be associated with vascular thrombosis due to antiphospholipid antibodies. Accumulating evidence indicates that renal microvascular thrombosis due to lupus anticoagulant is an independent risk factor for poor renal outcome in lupus nephritis [1, 2]. In this report, we present a young woman with diffuse proliferative lupus nephritis and glomerular microthrombosis associated with lupus anticoagulant. Whereas MMF and glucocorticoids failed to induce remission, therapeutic plasma exchange (TPE) led to rapid clinical and immunological recovery.
منابع مشابه
Efficacy of plasma exchange and immunoadsorption in systemic lupus erythematosus and antiphospholipid syndrome: A systematic review.
Extracorporeal treatments have been used since the 1970s in the management of systemic lupus erythematosus (SLE). A randomised controlled trial comparing the efficacy of standard of care (SOC) combined with plasma exchange against SOC alone in patients with lupus nephritis revealed no difference in terms of renal outcome. Subsequently, initial expectations have been dampened and further experie...
متن کاملSignificance of anticardiolipin and anti-beta(2)-glycoprotein I antibodies in lupus nephritis.
OBJECTIVE To investigate whether anticardiolipin (aCL) and anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibodies are associated with lupus nephritis (group II patients), and whether there are differences in the prevalence of these two autoantibodies between group II patients and patients with non-nephritis SLE (group I) and primary antiphospholipid syndrome (PAPS) patients (group III). MET...
متن کاملPrevalence of hepatitis C virus antibody in patients with systemic lupus erythematosus.
logic correlations of the antiphospholipid syndrome. Semin Arthritis Rheum 1995; 24:262-72. 2 Asherson RA. The catastrophic antiphospholipid syndrome. J Rheumatol 1992;19:508-12. 3 Asherson RA, Piette J-C. The catastrophic antiphospholipid syndrome 1996: acute multiorgan failure associated with antiphospholipid antibodies: a review of 31 patients. Lupus 1996;5:414-7. 4 Mazzucchelli R, Barbadill...
متن کاملAcute Unilateral Blindness from Superior Ophthalmic Vein Thrombosis: A Rare Presentation of Nephrotic Syndrome from Class IV Lupus Nephritis in the Absence of Antiphospholipid or Anticardiolipin Syndrome
Patients with systemic lupus erythematosus (SLE) are at high risk of arterial and venous thrombosis secondary to anti-phospholipid antibodies. Herein, we are presenting an interesting case of venous thrombosis in a patient with SLE in the absence of anti-phospholipid antibodies.
متن کاملCerebral thrombosis in systemic lupus erythematosus with the antibody antiphospholipid syndrome.
Systemic lupus erythematosus (SLE) has numerous manifestations. Haematology is the common system influenced by the disease. The antibody antiphospholipid syndrome, secondary hematology disorder in SLE, is related to high incidence of thrombosis. The thrombosis events like myocardial infarction and stroke are high in mortality. We reported a-36-year old woman treated for lung tuberculosis (TB) w...
متن کامل